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Choosing primary endpoints for clinical trials of health care interventionsThis narrative review describes the evolution, range and relative strengths and weaknesses of endpoints used in late phase trials
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Genetic determinants of paediatric food allergy: A systematic reviewWe systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation
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Coffee and tea consumption during pregnancy and risk of childhood acute myeloid leukemia: A Childhood Leukemia International Consortium (CLIC) studyWe investigated the potential association of maternal coffee and tea consumption during pregnancy with childhood acute myeloid leukemia risk
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Sun-immune connectionExposure to ultraviolet radiation damages skin cell DNA but skin cancers develop because ultraviolet radiation also affects the immune system
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Paediatric asylum seekers in Western Australia: Identification of adversity and complex needs through comprehensive refugee health assessmentPaediatric asylum seekers have complex trauma backgrounds with exposure to multiple adverse events within disrupted family units
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Quorum Sensing Signaling Alters Virulence Potential and Population Dynamics in Complex Microbiome-Host InteractomesGenome sequencing and phylogenetic analysis of a quorum sensing positive Psychrobacter isolate identified several quorum sensing associated systems
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An assessment of computer-generated stimuli for use in studies of body size estimation and biasOur results show that perception of body size for computer-generated stimuli was non-linear
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Investing in school readiness: A comparison of different early childhood education pathways in rural IndonesiaThis paper documents that children in rural Indonesia participate in a great variety of early childhood education pathways
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Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndromeStructural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown.
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Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in AdultsConventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective licensed vaccines for tuberculosis, HIV, respiratory syncytial virus, and other major infections of global significance. Approaches at rational vaccine design have been limited by our understanding of the immune response to vaccination at the molecular level. Tools now exist to undertake in-depth analysis using systems biology approaches, but to be fully realized, studies are required in humans with intensive blood and tissue sampling.