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Research

MK2 inhibition induces p53-dependent senescence in glioblastoma cells

In response to DNA damaging chemotherapy, targeting MK2 in p53-mutated cells produces a phenotype that is distinct from the p53-deficient phenotype

Research

Priorities for improved management of acute rheumatic fever and rheumatic heart disease

The results suggest that timely injection and patient education are priorities for managing ARF and RHD, particularly focusing on child-to-adult transition care.

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Facilitators and barriers to the implementation of motivational interviewing for bullying perpetration in school settings

Results indicated a number factors which influenced the uptake of Motivational Interviewing in schools

Research

Psychosocial disadvantage and residential remoteness is associated with Aboriginal women's mental health prior to childbirth

Optimal mental health in the pre-conception, pregnancy and postpartum periods is important for both maternal and infant wellbeing. Few studies, however, have focused on Indigenous women and the specific risk and protective factors that may prompt vulnerability to perinatal mental disorders in this culturally diverse population.

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Qualitative study of psychosocial factors impacting on Aboriginal women's management of chronic disease

The caring roles and responsibilities Aboriginal women have in their community impact on their health

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Child and adolescent psychiatry training in Australia and New Zealand

This article highlights the requirements of the training programs for Child and Adolescent Psychiatry in Australia and New Zealand

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Laryngeal reflex responses in pediatric anesthesia

Laryngeal and respiratory reflexes are vitally important defense mechanisms against foreign body aspiration, safeguarding airway patency, and ventilation

Research

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019.

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The high prevalence and impact of rheumatic heart disease in pregnancy in First Nations populations in a high-income setting: a prospective cohort study

Rheumatic heart disease in pregnancy persists in First Nations people in Australia and New Zealand and is associated with major cardiac and perinatal morbidity

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Shade coverage, ultraviolet radiation and children’s physical activity in early childhood education and care

The provision of shade, particularly through natural forms such as tree canopy, is an important sun protection strategy and enabler of outdoor time