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Research
Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemiaOur findings shed light on the mechanisms of leukemia-induced bone loss
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Dietary protein affects both the dose and pattern of insulin delivery required to achieve postprandial euglycaemia in Type 1 diabetes: a randomized trialA high-protein meal requires ~50% more insulin to maintain euglycaemia than a low-protein meal that contains the same quantity of carbohydrate
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Common Pathways to NSSI and Suicide Ideation: The Roles of Rumination and Self-CompassionThe salience of self-compassion offers promise for early intervention initiatives focusing on less judgmental or self-critical means of self-relation
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Research priorities for childhood chronic conditions: a workshop reportResearch priorities emphasise a focus on life participation, psychosocial well-being, impact on family and quality of care
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Persistent negative symptoms in individuals at Ultra High Risk for psychosisPersistent negative symptoms can be detected early, allowing for the identification of a subset of Ultra High Risk patients who are likely to have poor outcome
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Tissue-resident memory T cells orchestrate tumour-immune equilibriumOur findings provide insight into the immune cell populations important for maintaining long-term tumour dormancy in peripheral tissues
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Environmental and social determinants of acute rheumatic fever: a longitudinal cohort studyPrevention strategies in ARF endemic settings may be enhanced by targeting new members entering a community and children in environments of close contact
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The ORIGINS ProjectORIGINS is a new birth cohort study, collecting detailed information about the early environment's influence on a broad range of non-communicable diseases
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Maternal pre-pregnancy weight and autistic-like traits among offspring in the general populationThis study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring
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Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: An integrative reviewWe review medical conditions that have been repeatedly highlighted as sharing the strongest associations with ASD-epilepsy, sleep, as well as gastrointestinal and immune functioning