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The current study aimed to examine the influence of distinct patterns of prenatal alcohol exposure and postnatal threat and deprivation during infancy on sleep outcomes at three-years. Data were derived from a longitudinal cohort originating from predominately low-income hospital settings in Australia.
Clinical trial designs are typically narrowly focused on error control in hypothesis testing, but this approach is inadequate in many contexts, particularly when a decision maker intends to, or must, consider multiple relevant clinical and health economic outcomes under uncertainty. Value-of-information (VoI) metrics can be used to estimate the monetary value of data collection to the decision maker.
Indigenous communities are under-represented in genomics research, contributing to inequitable health-related knowledge, outcomes, and benefits. Under-representation reflects enduring consequences of colonial research practices that have engendered cultural, ethical, legal, and social (CELS) concerns among communities.
With young adults' rates of mental health problems alarmingly high, understanding resilience characteristics that help young people adapt, adjust, and even thrive in the face of stress is a pressing need. This study takes a daily diary approach, examining four resilience factors, measured a priori, covering multiple domains. Young adults' daily stress responses (reactivity, recovery, inertia) during the globally stressful lockdown period three years later were then explored as key outcomes.
BK polyomavirus (BKPyV) is a common opportunistic infection in kidney transplant recipients, typically reactivating in the context of immunosuppression. Although asymptomatic in immunocompetent individuals, reactivation in transplant recipients can cause BKPyV-associated nephropathy (BKPyVAN), a leading cause of graft dysfunction and loss. BKPyV viremia affects approximately 10%-15% of transplant recipients, and once BKPyVAN is established, the risk of graft failure can exceed 50%.
There is a greater prevalence of multiple sclerosis (MS), a neurological autoimmune condition, in populations living further from the equator, hypothesised to be due to reduced sunlight exposure. There exists a proven sunlight surrogate therapy for dermatological inflammatory conditions, in the form of narrowband NB-UVB phototherapy. Yet, there is a paucity of randomized trials of the therapeutic delivery of NB-UVB beyond dermatology for conditions with a systemic inflammatory component.
Sensory integration therapy is used widely despite an inconsistent evidence base. To overcome the limited availability of high-quality research, Ayres Sensory Integration (ASI) was manualized and a revised fidelity measure was developed following the identification of the principles of ASI®. The aim of this systematic review is to examine the proximal and distal effects of interventions in studies that explicitly reported the use of or adherence to the process elements of the fidelity measure.
Heated-tobacco-products (HTPs) are electronic devices that "heat" a processed tobacco/chemical mixture to produce an inhalable emission. They are advertised as a reduced-risk alternative to cigarette smoking. The aim of our research was to assess their potential health impacts using a 3D human airway model.
We conducted the non-invasive surveillance of Plasmodium knowlesi in wild macaques using 4,752 faecal samples collected across nine endemic countries.
We investigated the genetic and epigenetic regulation of the UBASH3A gene and its association with early-onset sepsis. Using matched whole blood DNA methylation, gene expression, genotypes, and immune cell counts from the EPIC-HIPC newborn cohort, we report that promoter methylation was negatively correlated with ontogenetic changes in UBASH3A gene expression and circulating CD3+ T-cell numbers.