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Research

Skin tumor immunity: Site does matter for antigen presentation by DCs

Timely mobilization of tumor antigen-bearing dendritic cells (DCs) from the periphery to the lymph nodes is critical for effective antitumor T-cell immunity

Research

Exploring local government areas with significant shifts in child development between 2009 and 2012 on the Australian Early Development Census

This project analysed AEDC results across Australia, to identify communities with significant improvement (decreases in developmental vulnerability) between 2009 and 2012

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Regular peaks and troughs in the Australian incidence of childhood type 1 diabetes mellitus (2000–2011).

This study aimed to determine the incidence and incidence rate trends of type 1 diabetes mellitus in children aged 0–14 years...

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Longitudinal research: Applications for the design, conduct and dissemination of early childhood research

The conduct of longitudinal research in early childhood is the focus of this chap­ter

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Linked data research: a valuable tool in the ART field

This letter to the editor endorses data linkage studies and cites their potential value over other types of epidemiological studies within the field of...

Research

Children and young people at risk of disengagement from school

The review examines the international literature to determine how disengagement can be defined & understood, & then examines student disengagement in Australia.

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Airway management in the paediatric difficult intubation registry: a propensity score matched analysis of outcomes over time

The Paediatric Difficult Intubation Collaborative identified multiple attempts and persistence with direct laryngoscopy as risk factors for complications in children with difficult tracheal intubations and subsequently engaged in initiatives to reduce repeated attempts and persistence with direct laryngoscopy in children. We hypothesised these efforts would lead to fewer attempts, fewer direct laryngoscopy attempts and decrease complications.

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Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children

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Airway narrowing assessed by anatomical optical coherence tomography in vitro: dynamic airway wall morphology and function

Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations.

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Analytical bias in the measurement of serum 25-hydroxyVitamin D concentrations impairs assessment of Vitamin D status

This publication demonstrated considerable differences in the measurement of 25-hydroxyvitamin D concentrations compared with a certified laboratory, even...

Research

Airway smooth muscle thickness and contraction are enhanced by intra-amniotic lipopolysaccharide in an ovine model of premature birth

Abnormalities of the airway smooth muscle (ASM) layer in asthma may develop before birth. We hypothesize that antenatal inflammation causes physiological abnormalities of the ASM that predisposes asthma. This study determined the short-term effects of antenatal inflammation on the developing ASM.

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Psychosocial characteristics and predictors of health-care use in families of young children with cystic fibrosis in Western Australia

This study aimed to identify psychosocial predictors in cystic fibrosis that may inform intervention strategies.

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Using online environments to build school staff capacity to address student wellbeing

Professional development of school staff can be enhanced with carefully developed and delivered online learning resources

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Airway surface liquid pH is not acidic in children with cystic fibrosis

Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting.

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A comparison of paediatric and adult infectious diseases consultations in Australia and New Zealand

The objective of this paper is to describe paediatric infectious diseases consultations across Australia and New Zealand.

Airway surface liquid pH is not acidic in children with cystic fibrosis

Airway surface liquid pH is not acidic in children with cystic fibrosis Discover. Prevent. Cure. Modulation of airway surface liquid (ASL) pH has

Research

Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model

Airway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling.