Reports and Findings
Research
CASSETTE-clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: Study protocol for a randomised controlled trialThis study will assess the effect of adjunctive clindamycin on patient-centred outcomes in severe, toxin-mediated S. aureus infections
Research
Identification of an Esterase Isolated Using Metagenomic Technology which Displays an Unusual Substrate Scope and its Characterisation as an Enantioselective BiocatalystEvaluation of an esterase annotated as 26D isolated from a marine metagenomic library is described
Research
Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection studyWe review the Group A Streptococcus Human infection studies and present the study protocol for a dose-ranging inpatient study in healthy adults
Research
Survival and mortality in cerebral palsy: Observations to the sixth decade from a data linkage study of a total population register and National Death IndexSince 1990 mortality for those with severe cerebral palsy in Western Australia has tended to shift from childhood to early adulthood
Research
The controlled direct effect of temperament at 2-3 years on cognitive and academic outcomes at 6-7 yearsOverall, temperament had small associations with cognitive and academic outcomes after accounting for parenting and confounders
Research
Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discoveryThis review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response
Research
Acquired resistance during adoptive cell therapy by transcriptional silencing of immunogenic antigensThese findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control
Research
Implementing and Evaluating Interventions to Improve School Readiness and Early LiteracyThe implementation of the Pacific early age readiness and learning program has generated significant data, evidence, operational experience, and knowledge
Research
Comparing adolescent and parent reports of externalizing problems: A longitudinal population-based studySubstance use, depression and low school motivation impacted on discrepancy in externalizing behaviour scores for 14-year-old male adolescents and their parents
Research
Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic ApproachIn this article, we examine the utility of a transdiagnostic, dimensional approach to very early identification and intervention for infants at risk of neurodevelopmental disorders