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The interaction of genetic and environmental contributions to immunological traits and their association with atopic disease remain unclear. Flow cytometry and in vitro cytokine responses were used to characterize immune profiles from 93 school-aged twin pairs. Using an established twin pair analytical strategy, the genetic and environmental influences on immunological traits were evaluated, along with their association with atopy. Our findings suggest strong genetic influence on several traits, particularly B cell abundance. In contrast, cytokine responses from in vitro stimulations appeared mainly shaped by environmental exposures.
Sex hormones, such as oestrogen and testosterone, display significant immune modulatory properties. This is highly relevant for transgender (trans) people who undergo gender-affirming hormone (GAH) treatment. However, only a limited number of studies have evaluated the immunological impact of GAH treatments, and almost none have assessed the impact in trans young people.
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Biostatistics & Data Services
We unite experts and communities to improve child health through research that has impact, using animals only when no other methods are suitable. We are also a signatory to the ANZCCART Animals in Research Openness Agreement.
Flow cytometry is a technology used to measure complex cell phenotype and functions. Our Flow Facility is equipped with 3 flow cytometers/analysers, one...
The Kids has a range of specialised expertise, tools, platforms and technology to undertake cutting-edge science.
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