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ARC is a global network of collaborators committed to reducing the burden of RHD in our lifetime.
The goal of the program is to establish the foundations of an effective, sustainable and equitable response to RHD in the Pacific.
The Strep A Burden of Disease Working Group (BoDWG) was first established in 2020 through the Strep A Global Vaccine Consortium (SAVAC).
Goal: Characterize the pattern of contemporary and endemic ARF and develop a biological signature to improve sensitivity and specificity of ARF diagnosis.
In this study we will use new methods to comprehensively test immune responses in blood samples from people with ARF (diagnosed using the Jones Criteria) and healthy volunteers at Royal Darwin and from Auckland Hospital, New Zealand, to find any unique signature that reliably identifies ARF.
The key objective of this study is to collect data about patient and clinician preferences about reformulations.
This project will use a multi-jurisdictional linked RHD dataset to establish a baseline burden of RHD in Australia to allow for monitoring the impact of burden over time, and to form the basis of clearly defined targets for the END RHD CRE Endgame Strategy.
Aims: To determine the minimum inhibitory concentrations of penicillin G against a representative collection of Strep A strains; and to evaluate the impact of penicillin G concentration and size of bacterial inoculum on the prophylactic effect for Strep A strains
This project aims to develop a longer acting formulation of penicillin, such that frequency of the injection can be increased up to 3-6 months.
The main objective of the study is to establish a comprehensive register of congenital and acquired heart disease in WA with accurate re-classification of all cases through Princess Margart Hospital using international diagnostic codes.