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Pregnancy is an opportunistic time for dietary intake to influence future disease susceptibility in offspring later in life. The ORIGINS Project was established to identify the factors that contribute to 'a healthy start to life' through a focus supporting childhood health and preventing disease (including non-communicable diseases).
Although many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers.
The aim of this review was to map the literature assessing associations between maternal or infant immune or gut microbiome biomarkers and child neurodevelopmental outcomes within the first 5 years of life. We conducted a PRISMA-ScR compliant review of peer-reviewed, English-language journal articles.
This study aims to examine how a Mediterranean diet and exercise in pregnancy impacts on neonatal body fat composition at birth and weight at one year of age.
Urine is an attractive biospecimen for nutritional status and population health surveys. It is an excellent non-invasive alternative to blood for appropriate biomarkers in young children and is suitable for home-based collection, enabling representative collections across a population. However, the bulk of literature in this population is restricted to collection in primary care settings.
Publications, papers and findings coming out of ORIGINS and its sub-projects
Positive mental health, flourishing, and resilience to stress are not only critical to the overall wellbeing of a person but also their physical health, affecting both chronic and acute health conditions
This research aims to examine subfertility in a population pregnancy cohort, analysing the underlying differences between sub fertile couples who conceive naturally, sub fertile couples who conceive using ART or non-IVF, and fertile couples.
Exploring whether urinary ferritin can be used as an alternative biomarker for measuring iron status in young children over blood draws.
ORIGINS has several sub-projects exploring allergy development within the cohort, with a focus on respiratory conditions such as asthma and nutritional strategies for allergy prevention.