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The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients.
The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus.
This study helps us understand how cancer cells are regulated by key genes and their corresponding networks to alter their fate in response to specific...
Examining the overlap between genes perturbed in the KD-CAGE experiments and genes with a ChIP-seq peak within 50 kb of their promoter, we identified direct...
Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during...
The immediate-early response mediates cell fate in response to a variety of extracellular stimuli and is dysregulated in many cancers.
The generation of myeloid cells from their progenitors is regulated at the level of transcription by combinatorial control of key transcription factors...
The FANTOM5 project investigates transcription initiation activities in more than 1,000 human and mouse primary cells, cell lines and tissues using CAGE.
Arguably the most basic step in the analysis of next generation sequencing data (NGS) involves the extraction of mappable reads from the raw reads...
This study reports that telomerase reverse transcriptase extensively affects the expression levels of mature microRNAs.