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Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations

Atopic asthma, which is at its highest prevalence during childhood/young adulthood, represents the main focus of this review.

Th2-polarisation of cellular immune memory to neonatal pertussis vaccination

Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular...

Early immunological influences on asthma development: opportunities for early intervention

The developing immune system and allergy

Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infection

Early aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection

Professor Pat Holt

Emeritus Honorary Researcher

Primary prevention of severe lower respiratory illnesses in at-risk infants using the immunomodulator OM-85

The effects of OM-85 were strongest in the first winter season, with a trend for fewer children in the OM-85 group to have sLRIs and URIs

Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children

The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children

Personalized transcriptomics reveals heterogeneous immunophenotypes in children with viral bronchiolitis

Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants

Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus Infection

Pregnancy is associated with an alternatively activated phenotype of alveolar macrophage before infection