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Influence of gestational age on dead space and alveolar ventilation in preterm infants ventilated with volume guarantee

Ventilated preterm infant lungs are vulnerable to overdistension and underinflation.

Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection

Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung...

Route of exposure alters inflammation and lung function responses to diesel exhaust

In this study, we compared the physiological consequences of short-term exposure to diesel exhaust via inhalation to those due to exposure to the same diesel...

Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice

In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to...

The concentration of iron in real-world geogenic PM10 is associated with increased inflammation and deficits in lung function in mice

Mineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community...

The influence of moving walls on respiratory aerosol deposition modelling

This work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel...

In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice

All alterations to lung mechanics following in utero arsenic exposure were recovered by adulthood.

The health effects of electronic cigarettes

Alexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids

Understanding how viral infection in early life impacts on lung function in adulthood

Alexander David Deborah Larcombe Martino Strickland BScEnv (Hons) PhD BSc PhD PhD Honorary Research Fellow Head, Chronic Diseases Research Head,

Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model

Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.