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Maltreated children are at high risk for low educational achievement, however few studies have accounted for confounding risk factors that commonly co-occur (including child, family and neighbourhood risk factors) and results have been mixed, particularly for adolescents.

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This article reports on a study in Australia which sought to utilise the characteristics to identify positive veteran teachers within a larger cohort

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We report an 8 year old girl who was diagnosed with THES by the Undiagnosed Disease Program-WA with compound heterozygous pathogenic variants in SKIV2L

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This paper is the first to explore whether differences in time use by children of Asian-born parents may help to explain the observed differentials in school achievements

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While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tumors before and after cyclophosphamide, and compare the gene expression profiles of responders with progressors.

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ADHD patients showed substantially diminished intrinsic coupling for 7 connections and increased coupling for 4 connections

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SETBP1 Haploinsufficiency Disorder (SETBD) is characterised by mild to moderate intellectual disability, speech and language impairment, mild motor developmental delay, behavioural issues, hypotonia, mild facial dysmorphisms, and vision impairment. Despite a clear link between SETBP1 mutations and neurodevelopmental disorders the precise role of SETBP1 in neural development remains elusive.

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Subjective memory complaints individuals present distinctive features of memory complaints as compared to non-memory complainers

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We hypothesised that the performance of variant prioriisation tools may vary by disease phenotype.

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In adolescents, bowel patterns and gastrointestinal symptoms are diverse and show sex differences

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The analysis of CAGE (Cap Analysis of Gene Expression) time-courses has been applied to examine the dynamics of enhancer and promoter by sequentially...

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This project forms Activity 3.5 of the Social Science Research Infrastructure Network (SSRIN) and focuses on the development of Indigenous-led guidelines to support the ethical, culturally appropriate use of government administrative data relating to Indigenous peoples.

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A comprehensive picture of the regulatory regions of the three genes involved in Rett Syndrome

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The ‘Building Social and Emotional Wellbeing Through the Arts Project’ was funded in 2021 by Healthway and supported through a partnership between The Kids Research Institute Australia and Edith Cowan University (ECU).

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Clinical deep phenotyping and phenotype annotation play a critical role in both the diagnosis of patients with rare disorders as well as in building computationally-tractable knowledge in the rare disorders field.

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Young men aged 18-25 years are at disproportionately increased risk for gambling problems compared to their older or female counterparts. The unique mechanisms that precipitate these problems in this group remain unclear. Data from the largest longitudinal cohort study on Australian men's health (the Ten to Men Study) were used to identify the psychosocial, health-related, and gambling-related behavioral predictors of problem gambling severity in 265 young men aged 18-25 years. Hierarchical multiple ordinal logistic regression analyses found these predictors to explain a moderate proportion of variance in problem gambling severity. 

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Although many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers. 

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Fathers remain less likely to participate in parenting interventions which can limit their ability to receive support and build their parenting capacity. The advent of social media has engendered novel opportunities for fathers to connect with, and support, one another in the form of online peer support. Growth of these online communities exemplifies the demand from fathers to relate to other fathers who are navigating parenthood. However, the benefits of membership to these communities remain unclear.

People

Feilman Fellow; Head, Precision Health Research and Head, Translational Intelligence