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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung functionPulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease.
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The hygiene hypothesis revisited: role of materno-fetal interactionsFor 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immu
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Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in AdolescentsThe extent to which maternal smoking in pregnancy (MSP) has persisting effects on respiratory health remains uncertain and the mechanisms involved are not...
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Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitisAtopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic...
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Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of ageThis paper examines whether a Vitamin D deficiency during pregnancy affects the child's lung function predisposition towards lung disease such as asthma.
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Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric ARI.
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Asthma is responsible for considerable global morbidity and health-care costs. Substantial progress was made against key outcomes such as hospital admissions with asthma and mortality in the 1990s and early 2000s, but little improvement has been observedWe aim to provide our view of where we are and where we need to go as a community of clinicians and researchers who tackle the public health problem of asthma.
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Environmental microbial exposure and protection against asthmaThis article looks at the clinical implications of the research into microbial exposure & protection against asthma.
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Timing of routine infant vaccinations and risk of food allergy and eczema at one year of ageThere was no overall association between delayed DTaP and food allergy; however, children with delayed DTaP had less eczema and less use of eczema medication
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Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) studyThis genome-wide association study (GWAS) utilises data from the Western Australian Pregnancy Cohort (Raine) Study for 25-hydroxyvitamin D (25(OH)D) levels...