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Probiotic peanut oral immunotherapy versus oral immunotherapy and placebo in children with peanut allergy in Australia (PPOIT-003): a multicentre, randomised, phase 2b trial

Oral immunotherapy is effective at inducing desensitisation to allergens and induces sustained unresponsiveness (ie, clinical remission) in a subset of patients, but causes frequent reactions. We aimed to investigate whether addition of a probiotic adjuvant improved the efficacy or safety of peanut oral immunotherapy.

Identifying gene network patterns and associated cellular immune responses in children with or without nut allergy

Although evidence suggests that the immune system plays a key role in the pathophysiology of nut allergy, the precise immunological mechanisms of nut allergy have not been systematically investigated. The aim of the present study was to identify gene network patterns and associated cellular immune responses in children with or without nut allergy.

Dysfunctional gut microbiome networks in childhood ige‐mediated food allergy

The development of food allergy has been reported to be related with the changes in the gut microbiome, however the specific microbe associated with the pathogenesis of food allergy remains elusive. This study aimed to comprehensively characterize the gut microbiome and identify individual or group gut microbes relating to food-allergy using 16S rRNA gene sequencing with network analysis.

Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case-control study of the association between pertussis vaccination in infancy

We therefore speculate that removal of wP from the vaccine schedule contributed to the observed rise in IgE-mediated food allergy among Australian infants

Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: A randomized controlled trial

Increased maternal egg ingestion is associated with increased breastmilk ovalbumin, and markers of immune tolerance in infants

Consensus of stakeholders on precautionary allergen labelling: A report from the Centre for Food and Allergy Research

Precautionary allergen labelling is the main tool available to indicate safety levels for food-allergic consumers with regard to potential allergens

Epigenetic modifications: Mechanisms of disease and biomarkers of food allergy

The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways.

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

This article discusses the relationships between gut colonization & inflammatory noncommunicable diseases, in regards to their treatment and prevention.

In-utero exposures and the evolving epidemiology of paediatric allergy

This paper discusses the rising prevalence of allergic disease in children. This review article considers recent findings in the field of paediatric immune...

Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy

Environmental exposures including maternal inflammation, diet, nutrient balance, microbial colonization and toxin exposures can directly and indirectly...