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Mechanical Abnormalities of the Airway Wall in Adult Mice After Intrauterine Growth RestrictionWe propose that mechanical abnormalities of the airway wall acquired through disrupted fetal growth impact susceptibility to disease
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Fuel feedstock determines biodiesel exhaust toxicity in a human airway epithelial cell exposure modelBiodiesel is promoted as a sustainable replacement for commercial diesel. Biodiesel fuel and exhaust properties change depending on the base feedstock oil/fat used during creation. The aims of this study were, for the first time, to compare the exhaust exposure health impacts of a wide range of biodiesels made from different feedstocks and relate these effects with the corresponding exhaust characteristics.
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Growth of the airway smooth muscle layer from late gestation to childhood is mediated initially by hypertrophy and subsequently hyperplasiaThe airway smooth muscle (ASM) layer thickens during development. Identifying the mechanism(s) for normal structural maturation of the ASM reveals pathways susceptible to disease processes. This study characterized thickening of the ASM layer from foetal life to childhood and elucidated the underlying mechanism in terms of hypertrophy, hyperplasia and extracellular matrix (ECM) deposition.
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Rhinovirus exacerbates house-dust-mite induced lung disease in adult miceIn this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to...
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The influence of moving walls on respiratory aerosol deposition modellingThis work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel...
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Acute diesel exhaust particle exposure increases viral titre and inflammation associated with existing influenzaExposure to diesel exhaust particles (DEP) is thought to exacerbate many pre-existing respiratory diseases.
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The concentration of iron in real-world geogenic PM10 is associated with increased inflammation and deficits in lung function in miceMineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community...
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Chronic carbon dioxide exposure: an unrecognised health risk of climate change?Alexander Larcombe BScEnv (Hons) PhD Head, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor
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Understanding how viral infection in early life impacts on lung function in adulthoodDavid Deborah Martino Strickland BSc PhD PhD Head, Clinical Epigenetics Program Head, Immunobiology and Immunotherapeutic Program David.Martino@
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Sexual dimorphism in lung function responses to acute influenza A infectionMales are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and...