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Research

ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents

Citation: Libman I, Haynes A, Lyons S, Pradeep P, Rwagasor E, et al. ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and

Research

Influences on the trajectory and subsequent outcomes in CDKL5 deficiency disorder

The study investigated the effect of seizure and medication burden at initial contact with the International CDKL5 Disorder Database on subsequent development and clinical severity and compared quality of life among those whose development progressed, remained stable, or regressed between baseline and follow-up.

Research

Consensus guidelines for antifungal stewardship, surveillance and infection prevention, 2021

Invasive fungal diseases (IFD) are serious infections associated with high mortality, particularly in immunocompromised patients. The prescribing of antifungal agents to prevent and treat IFD is associated with substantial economic burden on the health system, high rates of adverse drug reactions, significant drug-drug interactions and the emergence of antifungal resistance.

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Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli

We obtain a set of 57 candidate immediate early genes possessing promoters that consistently drive a rapid but transient increase in expression over time

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Associations between proposed local government liquor store size classifications and alcohol consumption in young adults

Young adults' alcohol consumption appears to be impacted by liquor store density and convenience, rather than outlet size

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Impact of the Friendly Schools whole-school intervention on transition to secondary school and adolescent bullying behaviour

These findings demonstrate the immediate value of whole-school interventions to reduce bullying behaviour and associated harms among students

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CrossTalk opposing view: Mucosal acidification does not drive early progressive lung disease in cystic fibrosis

Whether airway mucosal acidification drives early progressive lung disease is controversial

Research

The Gender Wage Gap in the Vietnamese Transition, 1993–2008

This essay examines wages and the gender wage gap between 1993 and 2008 in Vietnam

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Measuring the impact of genetic knowledge on intentions and attitudes of the community towards expanded preconception carrier screening

Having good genetic knowledge may not be enough to understand core concepts of preconception carrier screening

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If it's about me, why do it without me? Genuine student engagement in school cyberbullying education

This study reports on a three-year group randomized controlled trial, the Cyber Friendly Schools Project, aimed to reduce cyberbullying among grade 8 students