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Seizures, whether febrile or afebrile, occurring within 14 days following vaccination can be considered as vaccine proximate seizures (VPSs). While the attributable risk and clinical severity of first febrile VPS is well known, the risk and clinical outcomes of VPS recurrence is less well defined. We conducted a retrospective review of revaccination management and outcomes in children who experienced a VPS as their first seizure seen in Australian Specialist Immunisation Clinics between 2013 and 2017. Vaccination outcomes were compared between children who had a VPS as their only seizure (VPS only) and children who had further non-vaccine proximate seizures following their initial VPS (VPS+) prior to review at the clinic.
Advances in omics and specifically genomic technologies are increasingly transforming rare disease diagnosis. However, the benefits of these advances are disproportionately experienced within and between populations, with Indigenous populations frequently experiencing diagnostic and therapeutic inequities. The International Rare Disease Research Consortium (IRDiRC) multi-stakeholder partnership has been advancing toward the vision of all people living with a rare disease receiving an accurate diagnosis, care, and available therapy within 1 year of coming to medical attention. In order to further progress toward this vision, IRDiRC has created a taskforce to explore the access barriers to diagnosis of rare genetic diseases faced by Indigenous peoples, with a view of developing recommendations to overcome them.
These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control
The β-lactamase assays provide compatible tools for functional characterization of CPP activity and the delivery of biological cargos into cells
This study examines the association of autism spectrum traits, depressive symptoms and suicidal behaviour in individuals with psychotic experiences
Our findings demonstrate that Ultra-High-Risk groups evidence a similar clinical risk profile when we expand this beyond transition to psychosis
We conducted a randomized controlled trial of short message service (SMS) reminders for influenza vaccination.
The genetic causes of intellectual disability (ID) are heterogeneous and include both chromosomal and monogenic etiologies.
This is an exciting opportunity to join ORIGINS playing a key role in the coordination of the Project's data systems.
Support the new in vivo radiotherapy facility and other specialist research equipment at The Kids Research Institute Australia