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Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditionsAlthough genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form does not ameliorate disease. Genetic variation in genes regulating vitamin D, and regulated by vitamin D, affect MS risk.
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Sun-immune connectionExposure to ultraviolet radiation damages skin cell DNA but skin cancers develop because ultraviolet radiation also affects the immune system
Research
Vitamin D C3-epimer levels are proportionally higher with oral vitamin D supplementation compared to ultraviolet irradiation of skin in mice but not humansThe proportion of 25(OH)D3 that undergoes epimerization is greater with oral vitamin D3 supplementation than exposure to UVR in mice, but not in humans
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Ultraviolet irradiation of skin alters the faecal microbiome independently of vitamin D in miceSkin exposure to ultraviolet radiation alters the faecal microbiome, and further investigations to explore the implications of this in health and disease are warranted
News & Events
New research into Vitamin D and Sunlight has created Project D-LightProject D-Light aims to understand and harness the benefits of vitamin D and sunlight for Australian children while protecting them from excess UV.
News & Events
Vitamin D levels linked to depression in young menResearch from Perth's The Kids for Child Health Research shows that symptoms of depression in young men may be associated with low vitamin D levels.
News & Events
New research links poor language to lack of Vitamin D in wombNew research has found that children of mums who had low levels of Vitamin D during pregnancy are twice as likely to have language difficulties.
Research
World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin DVitamin D is involved in the regulation of the immune system and it may play a role in the development, severity and course of asthma and other allergic...
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Ultraviolet radiation, vitamin D and multiple sclerosisRecent work highlights both vitamin D and non-vitamin D effects on cellular immunity that suggests that higher levels of sun exposure and/or vitamin D status...
Research
Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescentsUsing prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin...