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Research

Microplastics Versus Microbiome: The Infantile Gut’s Battle for Health

Gut microbiota play a critical role in long-term health by supporting metabolism, immune function, inflammation regulation, and neurological development via the gut–brain axis. Beneficial bacteria enhance gut integrity through short-chain fatty acid production, pathogen inhibition, and mucosal barrier support.

Research

Longitudinal observational research study: establishing the Australasian Congenital Cytomegalovirus Register (ACMVR)

Congenital cytomegalovirus (cCMV) is an important cause of long-term childhood disability. In Australia, the identification and treatment practices and the long-term clinical and neurodevelopmental outcomes of children with cCMV are unknown.

Research

Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: Identifying biomarkers of vaccine responsiveness, respiratory infection, and asthma

Early-life immune development is a critical factor in predicting the risk of childhood respiratory infections, asthma, and poor vaccine responses. Identifying immune endotypes that predispose children to these conditions could lead to the development of predictive biomarkers and early interventions, potentially improving long-term health outcomes. 

Research

Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE

The pivotal phase 3 EPITOPE trial, a 12-month, double-blind, placebo-controlled study of epicutaneous immunotherapy with the VIASKIN patch containing 250 μg of peanut protein (VP250), previously reported significant treatment response versus placebo in peanut-allergic toddlers aged 1 through 3 years.

Research

The impact of maternal gestational stress on motor development in late childhood and adolescence: A longitudinal study

The purpose of this article is to investigate whether the number and timing of stressors experienced during pregnancy impacted longterm motor development at...

Research

Investigation of the Cross-National Equivalence of a Measurement of Early Child Development

This research paper reports on the results of investigating measurement invariance of the Early Development Instrument (EDI) in two South-Asian countries.

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Lao PDR. Early childhood education project Snapshot one: project background and baseline data demographics

This snapshot describes demographic information of the 7,520 children in the baseline sample, including where and how they live.

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Investing in School Readiness : An Analysis of the Cost-Effectiveness of Early Childhood Education Pathways in Rural Indonesia

This paper presents evidence on the cost-effectiveness of early childhood education pathways in rural Indonesia

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Exploring change in the Australian version of the Early Development Instrument

Calculating a critical difference for the percentage of children who are “at risk” and “on track” in addition to the children who are developmentally “vulnerable”

Research

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030.