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Insights into the associations between the gut microbiome, its metabolites and heart failureHeart failure (HF) is the end stage of most cardiovascular diseases and remains a significant health problem globally. We aimed to assess whether patients with left ventricular ejection fraction ≤45% had alterations in both the gut microbiome profile and production of associated metabolites when compared to a healthy cohort.
Research
Current understanding of the neutrophil transcriptome in health and diseaseNeutrophils are key cells of the innate immune system. It is now understood that this leukocyte population is diverse in both the basal composition and functional plasticity. Underlying this plasticity is a post-translational framework for rapidly achieving early activation states, but also a transcriptional capacity that is becoming increasingly recognized by immunologists.
Research
Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway diseaseMacrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis, neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior to chronic infection, suggesting a potential defect in macrophage immunomodulatory function.
Research
A pilot study of disease related education and psychotherapeutic support for unresolved grief in parents of children with CFDiagnosis of chronic disease in a child can result in unresolved grief (UG) in parents. This study aimed to evaluate the efficacy of psychological insight-oriented therapy (IOT) as a treatment for UG compared to disease related education in parents of children with cystic fibrosis. Sequence of delivery, first IOT then disease related education (or vice versa) was also examined, to let all participants experience both interventions.
The Wal-yan Respiratory Research Centre offers a broad range of outpatient and portable tests for those affected by chronic respiratory conditions.
News & Events
Kids Easy Breathing Study KickstartsThe Kids Easy Breathing Study kickstarts this month, with the aim of finding out how the airway surface is different between infants who develop chronic lung disease after contracting bronchiolitis compared with those who don’t.
News & Events
New study to better understand how bronchiectasis develops during childhoodA new research project – the WA Paediatric Bronchiectasis Cohort Study – officially commenced this month with the aim of looking at children with bronchiectasis in Western Australia, like nine-year-old Holly (pictured), to better understand how this disease develops during childhood.
News & Events
Unique twin study reveals clues to childhood allergiesA study published in Science Advances has revealed that while genetics play a significant role in shaping children's immune systems, environmental factors also influence key immune responses, offering opportunity for preventing allergic diseases.
News & Events
Vertex grant to support research into treatment strategies for cystic fibrosis lung diseaseDr Daniel Laucirica, a research officer with the Wal-yan Respiratory Research Centre, will undertake new research into potential treatment strategies to prevent lung damage in people with cystic fibrosis (CF), under the mentorship of Associate Professor Anthony Kicic - made possible by a Vertex Cyst
News & Events
Five innovative research projects supported by Inspiration Awards 2022Valued at a total of $440,000, the Wal-yan Respiratory Research Centre Inspiration Awards 2022 will support five cutting-edge research projects.