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Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivoThe objective of this study was to elucidate the molecular networks that underpin virus-induced exacerbations in asthmatic children in vivo.
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Hospitalisation with infection, asthma and allergy in Kawasaki disease patients and their families: genealogical analysis using linked population dataKawasaki disease results from an abnormal immunological response to one or more infectious triggers.
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Molecular characterization of Der p 10: A diagnostic marker for broad sensitization in house dust mite allergyTropomyosins represent clinically relevant seafood allergens but the role of mite tropomyosin
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CD4 allergen tetramersThe introduction of class II tetramers for identifying antigen-binding CD41 cells has lagged behind the use of class I tetramers because of difficulties...
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Influence of secular trends and sample size on reference equations for lung function testsThe aim of our study was to determine the contribution of secular trends and sample size to lung function reference equations, and establish the number...
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Infection and the development of allergic diseaseAn improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein...
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Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogenyWe sought to explore whether allergic children show differences in microbial Toll-like receptor (TLR)-mediated responses over their first 5 years of life.
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Linking lung function and inflammatory responses in ventilator-induced lung injuryDespite decades of research, the mechanisms of ventilator-induced lung injury are poorly understood...
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The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthmaThe glutathione S-transferase enzymes (GSTs) play an important role in the detoxification of environmental tobacco smoke (ETS), which contributes to airway infl
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1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responsesThe severity of allergic diseases may be modified by vitamin D. However, the immune pathways modulated by the active form of vitamin D, 1,25-dihydroxyvitamin D.