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Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT).
Atopic asthma, which is at its highest prevalence during childhood/young adulthood, represents the main focus of this review.
Current infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular...
Early immunological influences on asthma development: opportunities for early intervention
The developing immune system and allergy
Early aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection
AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment.
Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa.
Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolescents conceived without?
Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear.