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Australian infants who received whole-cell pertussis vaccines were less likely to be diagnosed with food allergy in childhood
Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.
Atopic dermatitis is a common inflammatory skin condition and prior genome-wide association studies have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date combining previously reported cohorts with additional available data.
The effects of OM-85 were strongest in the first winter season, with a trend for fewer children in the OM-85 group to have sLRIs and URIs
The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children
Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants
Pregnancy is associated with an alternatively activated phenotype of alveolar macrophage before infection
This protocol adapted an experimental animal model of disease for sensitization to ovalbumin during the immediate post-weaning period beginning at 21 days of age
Type 1 and 3 interferon response capacity appears strongly developmentally constrained at birth
There is a marked shift in innate and adaptive immune responses in Chinese immigrants after living in a Western environment for several years