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This study aimed to determine whether breathing 100% oxygen altered tidal breathing parameters in healthy young children and young children with CF.
Professor Stephen Stick has been awarded the prestigious Richard C. Talamo Distinguished Clinical Achievement Award from the US Cystic Fibrosis Foundation.
Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping"
Acinar ventilation inhomogeneity measured by single-breath washout was not associated with structural lung disease on CT
Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy
In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7% hypertonic saline improved the lung clearance index in children aged 3-6 years with cystic fibrosis, but it remained unclear whether improvement is also seen in structural lung disease. We aimed to assess the effect of inhaled hypertonic saline on chest CT imaging in children aged 3-6 years with cystic fibrosis.
Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF.
Whether airway mucosal acidification drives early progressive lung disease is controversial
This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates
Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target