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Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young childrenThe present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric acute respiratory infection (ARI).
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Population-based estimates of the effectiveness of pneumococcal vaccination in AustraliaAustralia’s Childhood Immunisation Register (ACIR) is one of only a handful of national immunisation registers world-wide.
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Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profilesthe association between infant LRTI and risk for persistent wheeze/asthma in this cohort is generally stronger for fLRTIs than for other infection categories
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Systems biology and big data in asthma and allergy: recent discoveries and emerging challengesWe describe recent "omic"-level findings, and examine how these findings have been systematically integrated to generate further insight
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Childhood atopy and mental health: a prospective, longitudinal investigationFindings are the first linking atopy (measured by both parent report and objective verification) with increased vulnerability to affective and anxiety problems
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The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stageAlthough debate surrounding the mechanism or mechanisms governing this causal pathway remains intense, demonstration of the capacity of pretreatment...
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Hospitalisation for bronchiolitis in infants is more common after elective caesarean deliveryThe authors previously reported an increased risk of hospitalisation for acute lower respiratory infection up to age 2 years in children delivered by...
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Gene polymorphisms, breast-feeding, and development of food sensitization in early childhoodThe effect of breast-feeding on the development of allergic disease is uncertain
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Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma controlThe hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation.
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Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthmaBacterial colonisation of the airways is associated with increased risk of childhood asthma