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The airway smooth muscle layer is structurally abnormal in low birth weight infants: implications for obstructive diseaseCitation: Wang KCW, Elliot JG, Saglani S, et al. The airway smooth muscle layer is structurally abnormal in low birth weight infants: implications
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RISING STARS: The heat is on: how does heat exposure cause pregnancy complications?The incidence and severity of heatwaves are increasing globally with concomitant health complications. Pregnancy is a critical time in the life course at risk of adverse health outcomes due to heat exposure. Dynamic physiological adaptations, which include altered thermoregulatory pathways, occur in pregnancy.
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Switching from tobacco cigarettes in very early pregnancy: The effects of in utero e-cigarette exposure on mouse offspring neurodevelopment and behaviourElectronic cigarettes (e-cigarettes) are often perceived to be safer than smoking, which has led to some women switching to e-cigarettes during pregnancy. However, the effects of switching from smoking to e-cigarettes on both pregnancy outcomes and the foetus are largely unknown. This study aimed to investigate the effects of switching from tobacco smoking to e-cigarette use in very early pregnancy on birth outcomes, neurodevelopment and behaviour of the offspring.
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Exposure to biodiesel exhaust is less harmful than exposure to mineral diesel exhaust on blood-brain barrier integrity in a murine modelEmerging data suggest that air pollution is a persistent source of neuroinflammation, reactive oxygen species, and neuropathology that contributes to central nervous system disorders. Previous research using animal models has shown that exposure to diesel exhaust causes considerable disruption of the blood-brain barrier, leading to marked neuroinflammation.
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Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of riskA hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial...
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Sexual dimorphism in lung function responses to acute influenza A infectionMales are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and...
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Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma controlThe hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation.
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Risk assessment for respiratory complications in paediatric anaesthesia: a prospective cohort studyPerioperative respiratory adverse events in children are one of the major causes of morbidity and mortality during paediatric anaesthesia.
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Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?From the results of well-performed population health studies, we now have excellent data demonstrating that deficits in adult lung function may be present early in life, possibly as a result of developmental disorders, incurring a lifelong risk of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease.
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Alcohol pharmacotherapy dispensing trends in Australia between 2006 and 2023This study aimed to investigate acamprosate and naltrexone dispensing patterns in Australia.