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Epigenetics in infectious diseasesViruses, bacteria, and parasites have developed strategies to invade and establish long-term infections in their hosts.
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Wound healing genes and susceptibility to cutaneous leishmaniasis in BrazilHere we examined single nucleotide polymorphisms (SNPs) in these genes as risk factors for cutaneous (CL) and mucosal leishmaniasis (ML), and leishmaniasis...
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Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous systemWe believe this data represents a useful resource to understand the central nervous system in macaque.
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Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal PopulationOur goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians.
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Human genetics of leishmania infectionsGWAS results provide firm confirmation for the importance of antigen presentation and the regulation of IFNγ in determining the outcome of Leishmania infections
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Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern BrazilOverall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts.
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Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in BrazilOur results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis
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Polygenic risk of ischemic stroke is associated with cognitive abilityFindings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability
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Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniaeDelayed development of antibodies to S. pneumoniae in infancy is associated with the development of atopy and asthma.
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First genome-wide association study in an Australian Aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetesA body mass index (BMI) >22kg/m2 is a risk factor for type 2 diabetes (T2D) in Aboriginal Australians.