Search
Research
Toxoplasma gondii infection is associated with mitochondrial dysfunction in-vitroOur results show perturbation of host mitochondrial function following T. gondii infection that likely impacts on pathogenesis of disease.
Research
Burkholderia pseudomallei evades Nramp1 (Slc11a1)- and NADPH oxidase-mediated killing in macrophages and exhibits Nramp1-dependent virulence gene expressionHere we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei.
Research
Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous systemWe believe this data represents a useful resource to understand the central nervous system in macaque.
Research
Early childhood development of boys with genital anomaliesWe found no increased risk of poor development among boys with hypospadias or undescended testis
Research
Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in BrazilOur results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis
Research
Polygenic risk of ischemic stroke is associated with cognitive abilityFindings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability
Research
Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniaeDelayed development of antibodies to S. pneumoniae in infancy is associated with the development of atopy and asthma.
Research
First genome-wide association study in an Australian Aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetesA body mass index (BMI) >22kg/m2 is a risk factor for type 2 diabetes (T2D) in Aboriginal Australians.
Research
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe)To investigate whether variants in cardiovascular candidate genes, some of which have been previously associated with type 2 diabetes (T2D), diabetic...
Research
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosisMultiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically...