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1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responsesThe severity of allergic diseases may be modified by vitamin D. However, the immune pathways modulated by the active form of vitamin D, 1,25-dihydroxyvitamin D.
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Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammat roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D. Arch Dermatol Res. 2018;310(3):221-30.We investigated the ability of topical 1,25(OH)2D to suppress contact dermatitis through an IL9 dependent process, examining mast cells and IL9 secreting cells.
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A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS studyThis study provides a basis for further studies to determine if there are any benefits of the therapeutic effects of narrowband UVB radiation on MS progression
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UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis.The prevalence of multiple sclerosis follows a latitude gradient, with increased disease at higher latitudes.
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Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRIThis study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease
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Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity StudyHigher UVR exposure at antigen sensitization was associated with a reduced delayed-type hypersensitivity response and altered T helper type 17 kinetics
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High-dose intramuscular Vitamin D provides long-lasting moderate increases in serum 25-hydroxVitamin D levels and shorter-Term changes in plasma calciumIntramuscular injection of a large bolus of Vitamin D effectively increases serum 25-hydroxyVitamin D levels without evidence of metabolic abnormality.
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The bioenergetics of inflammation: insights into obesity and type 2 diabetesDiabetes mellitus is one of the most common chronic metabolic disorders worldwide, and its incidence in Asian countries is alarmingly high.
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UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow–Differentiated Dendritic CellsA systemic immunosuppression follows UV irradiation of the skin of humans and mice.
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Assessing neutrophil subsets in autoimmune disease: Moving away from relying on density?Neutrophils are the most abundant immune cell in circulation. However, due to a number of technical challenges for researchers, including the neutrophil's short lifespan and difficulties with preservation, they are often discarded during blood processing and thus ignored in cohort studies. As such, the contribution of neutrophils to disease and their involvement in disease mechanisms is less explored compared with other immune cell types.