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Lung inflammation and simulated airway resistance in infants with cystic fibrosisCystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance.
Research
BAL Inflammatory Markers Can Predict Pulmonary Exacerbations in Children With Cystic FibrosisPulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. Research question: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obtained from BAL fluid?
Research
Microbiomic Analysis on Low Abundant Respiratory Biomass Samples; Improved Recovery of Microbial DNA From Bronchoalveolar Lavage FluidIn recent years the study of the commensal microbiota is driving a remarkable paradigm shift in our understanding of human physiology. However, intrinsic technical difficulties associated with investigating the Microbiomics of some body niches are hampering the development of new knowledge. This is particularly the case when investigating the functional role played by the human microbiota in modulating the physiology of key organ systems. A major hurdle in investigating specific Microbiome communities is linked to low bacterial density and susceptibility to bias caused by environmental contamination.
News & Events
Study finds high rates of chronic lung disease in remote-living Aboriginal childrenAlmost one in five children across four remote Kimberley communities has some form of chronic lung disease, according to a new study co-designed and conducted in partnership with Aboriginal communities.
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Researchers receive crucial near miss fundingCongratulations to three outstanding The Kids Research Institute Australia researchers who have received second chance WA health funding designed to support researchers who have narrowly missed out on highly competitive national funding.
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WA researchers lead global centre to eliminate childhood asthmaAn ambitious project that could stop children developing asthma is the centrepiece of a new world-class respiratory research centre launched in Perth.
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Could Perth lakes hold the secret to fighting antibiotic-resistant superbugs?Perth researchers have discovered a predatory virus living in the city’s lakes and rivers that can fight antibiotic-resistant superbugs in children.
Research
Prematurity-associated lung disease: is it asthma?Shannon Elizabeth Simpson Smith BMedSci (hons), PhD PhD, MSc, BSc Co-Head, Children's Lung Health; Senior Research Fellow Program Manager 08 6319
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New risk factor identified to help predict the long-term lung health of young adults born very pretermA study which set out to determine ways to predict the long-term lung health of young adults born very preterm has shown that a childhood history of respiratory hospital admission should be a key consideration in the management of preterm children and adults.
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New study to determine if it’s safe for children born preterm to attend day careA new study to determine if it’s safe for children who were born preterm to attend day care officially commenced this month.