Investigators: Chris Blyth, Deborah Lehmann, Kate Britton, Willie Pomat
Project description
Pneumococcal disease is an important cause of childhood morbidity and mortality worldwide. Evidence is required to support the introduction of pneumococcal conjugate vaccines (PCVs) in low-income and middle-income countries. PCVs prevent disease through both direct protection of vaccinated individuals, and indirect protection of unvaccinated people. This project aimed to determine the degree of this indirect effect after introduction of 13-valent PCV (PCV13) at three sites in Asia-Pacific, and describe the relationship between PCV coverage and indirect protection.
In the absence of feasible methods for pneumococcal disease surveillance in low-income and middle-income countries, studies of nasopharyngeal carriage of VT pneumococci, which is a prerequisite for disease, provide useful information to guide vaccine policy.
PneuCaPTIVE is a project which determines the proportion of children that need to be vaccinated in order to observe the associated herd impacts on community disease with benefits to unvaccinated children and adults
External collaborators
- Fiona Russell (Murdoch Children's Research Institute)
- Catherine Satzke (Murdoch Children's Research Institute)
- Kim Mulholland (Murdoch Children's Research Institute)
- Eileen Dunne (Murdoch Children's Research Institute)