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Coalition to Advance Vaccines Against Group A Streptococcus (CANVAS): A Trans-Tasman Initiative Against Rheumatic Fever

Investigators: Amy Baker, Jeffrey Cannon, Jonathan Carapetis, Katherine Gray, Yue Wu

External collaborators:

  • University of Auckland: Nikki Moreland, John Fraser, Diana Lennon
  • Otago University: Michael Baker
  • Griffith University: Michael Good, Michael Batzloff

CANVAS is a commitment by the Governments of Australia and New Zealand to advance the development of a vaccine against GAS infection, which can cause rheumatic fever.

The CANVAS program is evaluating potential vaccines currently under development to identify at least one that could proceed to clinical trials. The 3 main components to the CANVAS program are:

  1. obtaining a selection of the most common GAS strains
  2. testing potential vaccines against these strains
  3. undertaking an economic analysis to evaluate if vaccination is cost-effective.