Reports and Findings
Research
Rheumatic heart disease in pregnancy: How can health services adapt to the needs of Indigenous women? A qualitative studyHealth systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease
Research
Scabies and risk of skin sores in remote Australian Aboriginal communities: A self-controlled case series studyThe association between scabies and skin sores is highly significant and indicates a causal relationship
Research
Improving delivery of secondary prophylaxis for rheumatic heart disease in a high-burden setting: Outcome of a stepped-wedge, community, randomized trialThis strategy did not improve adherence to rheumatic heart disease secondary prophylaxis within the study time frame.
Research
Qualitative Evaluation of a Complex Intervention to Improve Rheumatic Heart Disease Secondary ProphylaxisA multifaceted intervention was implemented using quality improvement and chronic care model approaches to improve delivery of penicillin prophylaxis for rheumatic heart disease
Research
Evaluation of safety and immunogenicity of a group a streptococcus vaccine candidate (mj8vax) in a randomized clinical trialIntramuscular administration of novel acetylated peptide-protein conjugate vaccine candidate MJ8VAX was demonstrated to be safe and immunogenic
Research
Developing a human challenge model of GAS infectionNHMRC funding has been awarded for 4 years to Murdoch Childrens Research Institute for this project, with collaboration from Professor Jonathan Carapetis at The Kids.
Research
Calculation of the age of the first infection for skin sores and scabies in five remote communities in northern AustraliaThe young age of the first infection with skin sores and scabies reflects the high disease burden in these communities
Research
Fetal Alcohol Spectrum Disorder (FASD): Knowledge, attitudes, experiences and practices of the Western Australian youth custodial workforceThis study aims to establish the current knowledge, attitudes, experiences and practices regarding FASD and other neurodevelopmental impairments among youth custodial officers
Research
Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular MimicryRheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells.
Research
Development of an opsonophagocytic killing assay for Group A StreptococcusGroup A Streptococcus (GAS) or Streptococcus pyogenes is responsible for an estimated 500,000 deaths worldwide each year.