Effect of statins and ACE inhibitors on the metabolome in the Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT) cohort

Adolescence represents a pivotal period for the development of early diabetes-related vascular complications, primarily driven by chronic hyperglycemia and associated metabolic disturbances. Metabolomics provides a promising tool to identify biomarkers reflecting these early changes.

Citation:
Prampolini B, Giton A, Frassineti S, ……. Davis EA, Donaghue KC, Jones TW, Mahmud FH, et al. Effect of statins and ACE inhibitors on the metabolome in the Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT) cohort. Sci Rep. 2026;16(1).

Keywords:
AdDIT; Adolescents; Cardiovascular; Complications; Diabetes, type 1; Vascular diseases

Abstract:
Adolescence represents a pivotal period for the development of early diabetes-related vascular complications, primarily driven by chronic hyperglycemia and associated metabolic disturbances. Metabolomics provides a promising tool to identify biomarkers reflecting these early changes.