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Comparative evaluation of performance and precision of multiplex immunoassays measuring human IgG to Streptococcus pyogenes vaccine antigens

Streptococcus pyogenes (Group A Streptococcus, Strep A) is a Gram-positive bacterium and one of the most significant global bacterial pathogens, with disproportionate disease burden affecting low and middle-income countries. Despite substantial mortality and immune sequelae caused by Strep A, no licensed vaccines exist, and correlates of protection remain unestablished.

Citation:
Morici M, Gilmour J, Rossi O, ……. Dempsey Z, Massai L, ……. Cooper M, Serralha M, Frost H, Moriel DG, Carapetis J, Steer A, Fulurija A. Comparative evaluation of performance and precision of multiplex immunoassays measuring human IgG to Streptococcus pyogenes vaccine antigens. Frontiers in Immunology. 2026;Volume 17 - 2026.

Keywords:
Streptococcus pyogenes (GAS); analytical performance; antibody quantification; assay qualification; bead-based immunoassay; electrochemiluminescence; method comparison; multiplex immunoassay.

Abstract:
Streptococcus pyogenes (Group A Streptococcus, Strep A) is a Gram-positive bacterium and one of the most significant global bacterial pathogens, with disproportionate disease burden affecting low and middle-income countries. Despite substantial mortality and immune sequelae caused by Strep A, no licensed vaccines exist, and correlates of protection remain unestablished.