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Characterising symptomatic substates in individuals on the psychosis continuum: a hidden Markov modelling approach

To improve early intervention and personalise treatment for individuals early on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying and evaluating the movement between empirically derived attenuated psychotic symptomatic substates-clusters of symptoms that occur within individuals over time.

Citation:
Scott I, Aarts E, Wannan C, Gao ……. Cavve B, Hartmann JA, et al.  Characterising symptomatic substates in individuals on the psychosis continuum: a hidden Markov modelling approach. Psychol Med. 2025;55:e82.

Keywords:
Ambulatory assessment; Daily diary study; Ecological momentary assessment; Hidden markov model; clinical high risk; multilevel modelling; psychosis; psychosis continuum; psychosis states; symptom dynamics; ultra high risk

Abstract:
To improve early intervention and personalise treatment for individuals early on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying and evaluating the movement between empirically derived attenuated psychotic symptomatic substates-clusters of symptoms that occur within individuals over time.