IDH-mutant gliomas in children and adolescents - from biology to clinical trials

Gliomas account for nearly 30% of all primary central nervous system (CNS) tumors in children and adolescents and young adults (AYA), contributing to significant morbidity and mortality. The updated molecular classification of gliomas defines molecularly diverse subtypes with a spectrum of tumors associated with age-distinct incidence.

Citation:
Evans L, Trinder S, Dodgshun A, …….. Valvi S. IDH-mutant gliomas in children and adolescents - from biology to clinical trials. Front Oncol. 2024;14.

Keywords:
AYA; IDH mutation; adolescent and young adult; low grade glioma; pediatric

Abstract:
Gliomas account for nearly 30% of all primary central nervous system (CNS) tumors in children and adolescents and young adults (AYA), contributing to significant morbidity and mortality. The updated molecular classification of gliomas defines molecularly diverse subtypes with a spectrum of tumors associated with age-distinct incidence.