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Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial

To determine the efficacy of advanced hybrid closed-loop therapy in a high-risk cohort of youth on continuous subcutaneous insulin infusion with or without continuous glucose monitoring with suboptimal glycemia.

Citation:
Abraham MB, Smith GJ, Dart J, Clarke A, Bebbington K, Fairchild JM, Ambler GR, Cameron FJ, Davis EA, Jones TW. Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial. Diabetes Care. 2025;48(1):67-75. 

Keywords:
Blood glucose self-monitoring; analysis; metabolism; diabetes mellitus; type 1; drug therapy; psychology; 
glycated hemoglobin; administration & dosage; therapeutic use; quality of life; treatment outcome

Abstract:
To determine the efficacy of advanced hybrid closed-loop therapy in a high-risk cohort of youth on continuous subcutaneous insulin infusion with or without continuous glucose monitoring with suboptimal glycemia.