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Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children

Allergic sensitization and reduced ability to respond to viral infections may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells (pDC) are rare immune cells that produce type I interferons (IFN-I) and play a key role in orchestrating immune responses against viruses. 

Citation:
Coenen I, Jones AC, White AA, Takashima M, Lee WR, …… Strickland DH, Leffler J. Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children. Allergy: European Journal of Allergy and Clinical Immunology. 2025.

Keywords:
IgE; childhood asthma; interferon response; plasmacytoid dendritic cells

Abstract:
Allergic sensitization and reduced ability to respond to viral infections may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells (pDC) are rare immune cells that produce type I interferons (IFN-I) and play a key role in orchestrating immune responses against viruses.