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Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

Alcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure resembling common patterns of alcohol consumption in pregnancy in humans. 

Citation:
Bestry M, Larcombe AN, Kresoje N, Chivers EK, Bakker C, Fitzpatrick JP, ……. Buckberry S, Lister R, Symons M, Martino D. Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species. Elife. 2024;12.

Keywords:
DNA methylation; alcohol; developmental biology; epigeneome; genetics; genomics; human; mouse

Abstract:
Alcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure resembling common patterns of alcohol consumption in pregnancy in humans.