Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial

Bacille Calmette-Guérin (BCG) vaccination has off-target (non-specific) effects that are associated with protection against unrelated infections and decreased all-cause mortality in infants. We aimed to determine whether BCG vaccination prevents febrile and respiratory infections in adults.

Citation:
Pittet LF, Messina NL, McDonald E, …….. Manning L, Perrett KP, …….. Richmond PC, Rocha JL, et al for the BRACE Trial Consortium Group. Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial. eClinicalMedicine. 2024;72

Keywords:
Bacille Calmette-Guérin (BCG) vaccine; Health personnel; Heterologous; Immunity; Placebo; Primary prevention; Randomised controlled trial

Abstract:
Bacille Calmette-Guérin (BCG) vaccination has off-target (non-specific) effects that are associated with protection against unrelated infections and decreased all-cause mortality in infants. We aimed to determine whether BCG vaccination prevents febrile and respiratory infections in adults.