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Outcomes of rheumatic fever in Uganda: a prospective cohort study

Rheumatic heart disease is the largest contributor to cardiac-related mortality in children worldwide. Outcomes in endemic settings after its antecedent illness, acute rheumatic fever, are not well understood. We aimed to describe 3-5 year mortality, acute rheumatic fever recurrence, changes in carditis, and correlates of mortality after acute rheumatic fever. 

Citation:
Wirth SH, Pulle J, Seo J, Ollberding NJ, ……. Bowen AC, Parks T, Carapetis J, Okello E, et al. Outcomes of rheumatic fever in Uganda: a prospective cohort study. Lancet Global Health. 2024;12(3):e500-e8.  

Keywords:
Myocarditis; epidemiology; prospective studies; rheumatic fever; rheumatic heart disease; Uganda

Abstract:
Rheumatic heart disease is the largest contributor to cardiac-related mortality in children worldwide. Outcomes in endemic settings after its antecedent illness, acute rheumatic fever, are not well understood. We aimed to describe 3-5 year mortality, acute rheumatic fever recurrence, changes in carditis, and correlates of mortality after acute rheumatic fever.