Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis

The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals.

Citation:
Haas SS, Ge R, Agartz I, Amminger GP, …….. Lin A, Ma X, Mathalon DH, et al for the ENIGMA Clinical High Risk for Psychosis Working Group. Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis. JAMA Psychiatry. 2024;81(1):77-88

Keywords:
Neuroimaging; prodormal symptoms; diagnostic imaging; brain; case-control studies; psychotic disorders

Abstract:
The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals.