CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses

Whereas CD4+ T cells conventionally mediate antitumor immunity by providing help to CD8+ T cells, recent clinical studies have implied an important role for cytotoxic CD4+ T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4+ T cell responses and their regulation by major histocompatibility complex class II (MHC II) in the skin.

Citation:
Bawden EG, Wagner T, Schröder J, …….. Waithman J, Hochheiser K, Hölzel M, Gebhardt T. CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses. Sci Immunol. 2024;9(91):eadi9517.

Keywords:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; HLA antigens; histocompatability antigens Class 11; melanoma; skin neoplasms

Abstract:
Whereas CD4+ T cells conventionally mediate antitumor immunity by providing help to CD8+ T cells, recent clinical studies have implied an important role for cytotoxic CD4+ T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4+ T cell responses and their regulation by major histocompatibility complex class II (MHC II) in the skin.