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Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection

The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood.

Citation:
Mincham KT, Lauzon-Joset JF, Read JF, Holt PG, Stumbles PA, Strickland DH. Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection. Am J Respir Cell Mol Biol. 2024; 71(2):219-228.

Keywords:
Hematopoietic progenitors; PR8; extravascular lung; myeloid progenitors

Abstract:
The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood.