Genetic Correlates of Biological Aging and the Influence on Prediction of Mortality

Longevity and disease-free survival are influenced by a combination of genetics and lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may outperform chronological age in predicting health and longevity. This study investigated the relationship between genetic risks, lifestyle factors, and delta age (Δage), estimated as the difference between biological and chronological age.

Citation:
Akeju O, Mens MMJ, Warmerdam R, Dijkema M, van den Biggelaar AHJ, Franke L, et al. Genetic Correlates of Biological Aging and the Influence on Prediction of Mortality. J Gerontol A Biol Sci Med Sci. 2024;79(4).

Keywords:
Accelerated aging; Biomarkers; Environmental influences; Lifestyle; Polygenic scores

Abstract:
Longevity and disease-free survival are influenced by a combination of genetics and lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may outperform chronological age in predicting health and longevity. This study investigated the relationship between genetic risks, lifestyle factors, and delta age (Δage), estimated as the difference between biological and chronological age.