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Association between pertussis vaccination in infancy and childhood asthma: A population-based record linkage cohort study

Asthma is among the commonest noncommunicable diseases of childhood and often occurs with other atopic comorbidities. A previous case-control study found evidence that compared to children who received acellular pertussis (aP) vaccines in early infancy, children who received one or more doses of whole-cell pertussis (wP) vaccine had lower risk of developing IgE-mediated food allergy. We hypothesized that wP vaccination in early infancy might protect against atopic asthma in childhood. 

Citation:
Chacón GP, Fathima P, Jones M, Estcourt MJ, Gidding HF, Moore HC, Richmond PC, Snelling T. Association between pertussis vaccination in infancy and childhood asthma: A population-based record linkage cohort study. PLoS ONE. 2023;18 

Keywords:
Asthma; epidemiology; Australia; cohort studies; pertussis vaccine; retrospective studies; vaccination; whooping cough

Abstract:
Asthma is among the commonest noncommunicable diseases of childhood and often occurs with other atopic comorbidities. A previous case-control study found evidence that compared to children who received acellular pertussis (aP) vaccines in early infancy, children who received one or more doses of whole-cell pertussis (wP) vaccine had lower risk of developing IgE-mediated food allergy. We hypothesized that wP vaccination in early infancy might protect against atopic asthma in childhood.