Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model

Airway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling.

Citation:
Wang CJ, Smith JT, Lu D, Noble PB, Wang KCW. Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model. Clin Sci. 2023;137(19):1547-62.

Keywords:
Kiss1; Kiss1r; airway remodelling; airway-associated adipose tissue; obesity

Abstract:
Airway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling.