Prenatal depressive symptoms and childhood development of brain limbic and default mode network structure

Prenatal depressive symptoms are linked to negative child behavioral and cognitive outcomes and predict later psychopathology in adolescent children. Prior work links prenatal depressive symptoms to child brain structure in regions like the amygdala; however, the relationship between symptoms and the development of brain structure over time remains unclear.

Citation:
Donnici C, Long X, Reynolds J, Giesbrecht GF, et al. Prenatal depressive symptoms and childhood development of brain limbic and default mode network structure. Hum Brain Mapp. 2023

Keywords:
APrON; MRI; graph theory; prenatal depression; structural networks; white matter

Abstract:
Prenatal depressive symptoms are linked to negative child behavioral and cognitive outcomes and predict later psychopathology in adolescent children. Prior work links prenatal depressive symptoms to child brain structure in regions like the amygdala; however, the relationship between symptoms and the development of brain structure over time remains unclear.