The potential global cost-effectiveness of prospective Strep A vaccines and associated implementation efforts

Group A Streptococcus causes a wide range of diseases from relatively mild infections including pharyngitis to more severe illnesses such as invasive diseases and rheumatic heart disease (RHD). Our aim is to estimate the cost-effectiveness of a hypothetical Strep A vaccine on multiple disease manifestations at the global-level.

Citation:
Lee JS, Mogasale V, Kim S, Cannon J, Giannini F, Abbas K, Excler JL, Kim JH. The potential global cost-effectiveness of prospective Strep A vaccines and associated implementation efforts. NPJ Vaccines. 2023;8(1)

Keywords:
Group A Streptococcus; vaccination; rheumatic heart disease

Abstract:
Group A Streptococcus causes a wide range of diseases from relatively mild infections including pharyngitis to more severe illnesses such as invasive diseases and rheumatic heart disease (RHD). Our aim is to estimate the cost-effectiveness of a hypothetical Strep A vaccine on multiple disease manifestations at the global-level.