Interactions between the lipidome and genetic and environmental factors in autism

Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. Here we explored the plasma lipidome in 765 children (485 diagnosed with autism spectrum disorder (ASD)) within the Australian Autism Biobank.

Citation:
Yap CX, Henders AK, Alvares GA, Giles C, Huynh K, ……. Cleary D, Grove R, Hafekost C, Harun A, Holdsworth H, ……. Leslie J, Levis Frenk M, ……… Whitehouse AJO, Meikle PJ, Wray NR, Gratten J, The Busselton Health Study I. Interactions between the lipidome and genetic and environmental factors in autism. Nat Med. 2023;29(4):936-49.

Keywords:
Nuclear protein; autism; epidemiology; genetics; lipidomics; quality of life; sleep disorder; DNA helicases; transcription factors

Abstract:
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. Here we explored the plasma lipidome in 765 children (485 diagnosed with autism spectrum disorder (ASD)) within the Australian Autism Biobank.